The Bailey Lab
Engineering programmable cell therapies for solid tumors
We develop next-generation CAR-T cell therapies designed to overcome the physical, metabolic, and immune barriers that limit the treatment of solid tumors.
Our work integrates cellular engineering, tumor microenvironmental remodeling, spatiotemporal programming, and engagement of the endogenous immune system to build more effective and durable cancer immunotherapies.
What We Study
CELL ENGINEERING
Designing CAR-T cells with improved persistence and function in hostile solid tumor environments.
TME/ECM REMODELING
Targeting stromal and extracellular matrix barriers that prevent effective immune infiltration.
PROGRAMMABLE THERAPIES
Developing spatiotemporally-controllable cellular therapies to increase safety and efficacy.
ENDOGENOUS IMMUNITY
Designing therapies to recruit and activate the immune system to promote durable antitumor responses.
Cancer Focus
PEDIATRIC
Diffuse Midline Glioma
Neuroblastoma
Rhabdomyosarcoma
ADULT
Acute Myeloblastic Leukemia
Pancreatic Cancer
Breast Cancer
*Images are not our own.
Join Our Team
We are building a collaborative and creative team of scientists interested in CAR-T cell therapy, cancer immunology, tumor microenvironmental biology, spatial cellular programming, and translational immunoengineering.