The Bailey Lab
Engineering programmable cell therapies for solid tumors
We develop next-generation CAR-T cell therapies designed to overcome the physical, metabolic, and immune barriers that limit the treatment of solid tumors. Our work integrates cellular engineering, tumor microenvironmental remodeling, focused ultrasound, and engagement of the endogenous immune system to build more effective and durable cancer immunotherapies.
What We Study
CELL ENGINEERING
Designing CAR-T cells with improved persistence and function in hostile solid tumor environments.
TME/ECM REMODELING
Targeting stromal and extracellular matrix barriers that prevent effective immune infiltration.
PROGRAMMABLE THERAPIES
Developing focused ultrasound-responsive and locally activated cellular therapies to increase safety and efficacy.
ENDOGENOUS IMMUNITY
Designing therapies that recruit and activate the body’s own immune system to promote durable antitumor responses.
Cancer Focus
PEDIATRIC
Diffuse midline glioma
Neuroblastoma
Rhabdomyosarcoma
ADULT
Acute Myeloblastic Leukemia
Pancreatic Cancer
Breast Cancer
*Images are not our own. Photo credit (left to right): University of Michigan, iStock, CHLA, Cancer Research UK, MD Anderson, Britannica
Join our team
We are building a collaborative and creative team of scientists interested in CAR-T cell therapy, cancer immunology, tumor microenvironmental biology, focused ultrasound, and translational immunoengineering.